We stayed at Le Meridian hotel in Panama City and they arranged the private car with a driver who took us on a day long trip to Fort San Lorenzo and Leon. He was great, spoke excellent English and very courteous.

I ordered an Uber to take me to the location, to me that was the safest way to get around since I barely speak Spanish.

I use car rentals, all over Panama! No, problem.

Yes, you can. Take water and snacks with you.

I visited San Lorenzo s part of a tour to the new Panama Canal Locks. The tour was a walk in the jungle, San Lorenzo and the new locks. There were 4 people on the tour in a minibus. I found the tour on trip advisor while looking for tours of the new locks. It was $67.

There is no scheduled bus for it. You can only visit San Lorenzo with excursion buses

A taxi ride from Colon to San Lorenzo is possible, but it is a long ride and if on the meter could get a bit pricey. By far the most reasonable means of getting there and seeing it is with a private driver. This is definitely a half day attraction, so you'd want to negotiate accordingly. If it is just a driver, then negotiate a lower price than it was a tour guide and driver in one. If you are staying at a hotel in Colon, as them to help coordinate. When in Central and South America there is always a need to be just a little safer as things can and do happen to tourists. Uber is another option. But, when the car shows up, explain what you want to do to include the ride back and wait time. They can adjust the fare on their smartphone. Uber is typically cheaper than a taxi and the drivers are vetted. The taxi is really the last option I'd pick as you have no idea who you will have driving you down some very remote rode. Don't let the logistics of getting there keep you from going. San Lorenzo is well worth the effort and a place you will remember forever.

Not for limited mobility traveler.